1/13/2023 0 Comments Aquadine fish care specialist![]() ![]() To stimulate interest in the growing number of undergraduate allied health focused students, the theme of this laboratory exercise was focused on a medical problem a physician may face when attempting to rehabilitate a patient from a tissue injury to prevent further muscle/cellular damage due to the spread of the initial injury (Brancaccio et al., 2010 Cintra-Francischinelli et al., 2010). An invertebrate crayfish model was used which has a long history for college level teaching of neurophysiological principles. This educational module can also help establish other animal models which may lead to better treatment and assessment of deep tissue injury in urgent care centers for mammals.Ī university-level student laboratory exercise was designed around the theme of deep tissue injuries (DTIs) and related pathological consequences. Sample data is provided for the exercises presented. This can be caused by the additive effects of intracellular contents, particularly free K+, released from crushed muscle cells. Primary skeletal muscle damage can produce secondary effects which can increase the spread of the initial damage zone. The research questions on this topic are based on understanding the physiological problems associated with deep tissue injury of skeletal muscle and/or neurons. Crayfish motor units were used as the experimental model to determine the consequences of damaged muscle on surrounding healthy muscle and neuronal function. However, this exercise adopts a novel approach by studying extracellular K+ ions in the context of cellular injury alongside other contributing factors related to injury. Physiology exercises commonly study the effects of extracelluar K+ on resting membrane potential. This was examined by direct application of saline containing a higher than normal concentration of extracellular K+ ions. The research hypothesis states that muscle injury would result in a pathological increase in K+ concentration within muscle tissue, which would affect surrounding healthy cells. This is an ideal exercise as a course-based undergraduate research experience (CURE) to address authentic research questions. The exercise is left open-ended in several ways so instructors and students can modify it to tackle new questions. This laboratory procedure highlights neurophysiology exercises in synaptic transmission at neuromuscular junctions in relation to a practical problem. Limestone, Lexington, KY 40536-0200, USAĭepartment of Biology & Center for Muscle Biology, University of Kentucky, Lexington, KY 40506-0225, USA Institution Information: Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Hwy, Dayton, OH 45435, USAĭivision of Physical Therapy, Department of Rehabilitation Sciences, College of Health Sciences & Center for Muscle Biology, University of Kentucky, 900 S. ![]()
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